Induction of autoimmunity in good and poor responder mice with mouse thyroglobulin and lipopolysaccharide.
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Induction of autoimmunity in good and poor responder mice with mouse thyroglobulin and lipopolysaccharide
The administration of soluble mouse thyroglobulin (MTg) in conjunction with bacterial lipopolysaccharide (LPS) led to the termination of natural tolerance to MTg in mice. The extent of autoimmunity correlated with responsiveness to MTg, previously shown by the injection of MTg in complete Freund's adjuvant (CFA) to be dependent upon the H-2 haplotype. In good responder B10.BR (H-2k) mice given ...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1977
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.145.5.1250